Protein Details: Glutamate receptor-interacting protein 1
Protein ID
ICDB_Pro_0723
Protein Name
Glutamate receptor-interacting protein 1
Gene Name
Grip1
Organism
Rattus norvegicus (Rat)
Length
1112 amino acids
AlphaFoldDB
AF-P97879-F1-model_v4.pdb
Function
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Through complex formation with NSG1; GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
Sequence
Ligand Binding
Binding Site
Disease
Location
Expressed in brain; testis and retina. In brain highly expressed in the olfactory bulb; cortex and hippocampus and lower level in thalamus; cerebellum and spinal cord. In brain it is found in the perikaryon; dendrites; dendritic shafts; dendritic spines and; excitatory and inhibitory synapses of neurons. In brain it is found in the perikaryon; dendrites; dendritic shafts; dendritic spines and; excitatory and inhibitory synapses of neurons. In brain it is found in the perikaryon; dendrites; dendritic shafts; dendritic spines and; excitatory and inhibitory synapses of neurons. In retina; it is most abundant in the plexiform layers than in perikarya
DOI ID
10.1038/386279a0; 10.1074/jbc.m405786200; 10.1523/jneurosci.19-16-06930.1999; 10.1016/s0896-6273(00)81198-8; 10.1016/s0896-6273(02)00640-2; 10.1002/cne.10280; 10.1038/sj.emboj.7600755; 10.1016/j.cell.2011.03.016; 10.1038/ncomms1871; 10.1074/jbc.m207206200; 10.1074/jbc.m210010200; 10.1038/ng1292
RefSeq
NP_114458.1 [P97879-1]